Genflow Bioscience

Scientific Research

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Cell. 2019 Apr 18;177(3):622-638 

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Cell 124, 315–329 (2006)

Mostoslavsky, R. et al

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

Cell. 2009;136:62–74.

Kawahara TL, Michishita E, Adler AS, et al

Author manuscript; available in PMC 2019 Aug 1.

Han Dai, David A. Sinclair, James L. Ellis, Clemens Steegborn  Pharmacol Ther.

Aging genes: the sirtuin story unravels

Science. 2011;334:1194–1198.

Couzin-Frankel J. Genetics

SIRT6 promotes DNA repair under stress by activating PARP1

Z Mao, C Hine, X Tian, et al. 

Science 332. No.6036. June 2011: 1443-46

Epigenetics and longevity

Ageing Res Rev. 2017;40:11–19

Watroba M, Dudek I, Skoda M, Stangret A, Rzodkiewicz P, Szukiewicz D. Sirtuins

Luigi Fontana Interventions to Slow Aging in Humans: Are We Ready?

Aging Cell. 2015 Aug; 14(4): 497–510. 

Valter D Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K Ingram, Thomas E Johnson, Brian K Kennedy, Cynthia Kenyon, Samuel Klein, John J Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G Mirisola, James R Mitchell, Giuseppe Passarino, Karl L Rudolph, John M Sedivy, Gerald S Shadel, David A Sinclair, Stephen R Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra,

Metabolic control by sirtuins and other enzymes that sense NAD + , NADH, or their ratio.

Biochimica et Biophysica Acta (BBA) – Bioenergetics. 1858. 10.1016/j.bbabio.2017.09.005.

Anderson, Kristin & Madsen, Andreas & Olsen, Christian & Hirschey, Matthew. (2017).

The sirtuins, oxidative stress and aging: An emerging link

Aging. 5. 10.18632/aging.100544.

Merksamer, Philip & Liu, Yufei & He, Wenjuan & Hirschey, Matthew & Chen, Danica & Verdin, Eric. (2013).

Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling

Trends in biochemical sciences. 35. 669-75. 10.1016/j.tibs.2010.07.003.

Verdin, Eric & Hirschey, Matthew & Finley, Lydia & Haigis, Marcia. (2010)

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Cell Reports. 29. 4127-4143.e8. 10.1016/j.celrep.2019.11.067.

Naiman, Shoshana & Huynh, Frank & Gil, Reuven & Glick, Yair & Shahar, Yael & Touitou, Noga & Nahum, Liat & Avivi, Matan & Roichman, Asael & Kanfi, Yariv & Gertler, Asaf & Doniger, Tirza & Ilkayeva, Olga & Abramovich, Ifat & Yaron, Orly & Lerrer, Batia & Gottlieb, Eyal & Harris, Robert & Gerber, Doron & Cohen, Haim. (2019)

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

Nature Reviews Nephrology. 13. 10.1038/nrneph.2017.5.

Hershberger, Kathleen & Martin, Angelical & Hirschey, Matthew. (2017)

Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases.

Cell metabolism. 14. 718-9. 10.1016/j.cmet.2011.10.006.

Hirschey, Matthew. (2011)

Hormones, reproduction and disease in the longest-lived rodent: the naked mole rat

Endocrinology Studies. 1. 10.4081/es.2010.e4.

Vinciguerra, Manlio. (2013).

The sirtuin SIRT6 regulates lifespan in male mice

Nature. 2012;483:218–221.

Kanfi Y, Naiman S, Amir G, et al

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

Gerontol. A Biol. Sci. Med. Sci.

Roichman et al.

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Cell. 2019 Apr 18;177(3):622-638 

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Cell 124, 315–329 (2006)

Mostoslavsky, R. et al

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

Cell. 2009;136:62–74.

Kawahara TL, Michishita E, Adler AS, et al

Author manuscript; available in PMC 2019 Aug 1.

Han Dai, David A. Sinclair, James L. Ellis, Clemens Steegborn  Pharmacol Ther.

Aging genes: the sirtuin story unravels

Science. 2011;334:1194–1198.

Couzin-Frankel J. Genetics

SIRT6 promotes DNA repair under stress by activating PARP1

Z Mao, C Hine, X Tian, et al. 

Science 332. No.6036. June 2011: 1443-46