Genflow Bioscience

Scientific Research

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SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Cell. 2019 Apr 18;177(3):622-638 

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Cell Logo

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Cell 124, 315–329 (2006)

Mostoslavsky, R. et al

Cell Logo

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

Cell. 2009;136:62–74.

Kawahara TL, Michishita E, Adler AS, et al

Author manuscript; available in PMC 2019 Aug 1.

Han Dai, David A. Sinclair, James L. Ellis, Clemens Steegborn  Pharmacol Ther.

Science Aaas

Aging genes: the sirtuin story unravels

Science. 2011;334:1194–1198.

Couzin-Frankel J. Genetics

Science Aaas

SIRT6 promotes DNA repair under stress by activating PARP1

Z Mao, C Hine, X Tian, et al. 

Science 332. No.6036. June 2011: 1443-46

Aging Research Rev Cropped

Epigenetics and longevity

Ageing Res Rev. 2017;40:11–19

Watroba M, Dudek I, Skoda M, Stangret A, Rzodkiewicz P, Szukiewicz D. Sirtuins

Aging Cell

Luigi Fontana Interventions to Slow Aging in Humans: Are We Ready?

Aging Cell. 2015 Aug; 14(4): 497–510. 

Valter D Longo, Adam Antebi, Andrzej Bartke, Nir Barzilai, Holly M Brown-Borg, Calogero Caruso, Tyler J Curiel, Rafael de Cabo, Claudio Franceschi, David Gems, Donald K Ingram, Thomas E Johnson, Brian K Kennedy, Cynthia Kenyon, Samuel Klein, John J Kopchick, Guenter Lepperdinger, Frank Madeo, Mario G Mirisola, James R Mitchell, Giuseppe Passarino, Karl L Rudolph, John M Sedivy, Gerald S Shadel, David A Sinclair, Stephen R Spindler, Yousin Suh, Jan Vijg, Manlio Vinciguerra,

Bba Bioenergetics Cropped

Metabolic control by sirtuins and other enzymes that sense NAD + , NADH, or their ratio.

Biochimica et Biophysica Acta (BBA) – Bioenergetics. 1858. 10.1016/j.bbabio.2017.09.005.

Anderson, Kristin & Madsen, Andreas & Olsen, Christian & Hirschey, Matthew. (2017).

The sirtuins, oxidative stress and aging: An emerging link

Aging. 5. 10.18632/aging.100544.

Merksamer, Philip & Liu, Yufei & He, Wenjuan & Hirschey, Matthew & Chen, Danica & Verdin, Eric. (2013).

Bioscience 768x432

Sirtuin Regulation of Mitochondria - Energy Production, Apoptosis, and Signaling

Trends in biochemical sciences. 35. 669-75. 10.1016/j.tibs.2010.07.003.

Verdin, Eric & Hirschey, Matthew & Finley, Lydia & Haigis, Marcia. (2010)

Cell Reports Cropped

SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα

Cell Reports. 29. 4127-4143.e8. 10.1016/j.celrep.2019.11.067.

Naiman, Shoshana & Huynh, Frank & Gil, Reuven & Glick, Yair & Shahar, Yael & Touitou, Noga & Nahum, Liat & Avivi, Matan & Roichman, Asael & Kanfi, Yariv & Gertler, Asaf & Doniger, Tirza & Ilkayeva, Olga & Abramovich, Ifat & Yaron, Orly & Lerrer, Batia & Gottlieb, Eyal & Harris, Robert & Gerber, Doron & Cohen, Haim. (2019)

Nature Journal

Role of NAD+ and mitochondrial sirtuins in cardiac and renal diseases

Nature Reviews Nephrology. 13. 10.1038/nrneph.2017.5.

Hershberger, Kathleen & Martin, Angelical & Hirschey, Matthew. (2017)

Cell Metabolism Cropped

Old Enzymes, New Tricks: Sirtuins Are NAD(+)-Dependent De-acylases.

Cell metabolism. 14. 718-9. 10.1016/j.cmet.2011.10.006.

Hirschey, Matthew. (2011)

Jcem 768x432 Cropped

Hormones, reproduction and disease in the longest-lived rodent: the naked mole rat

Endocrinology Studies. 1. 10.4081/es.2010.e4.

Vinciguerra, Manlio. (2013).

Nature Journal

The sirtuin SIRT6 regulates lifespan in male mice

Nature. 2012;483:218–221.

Kanfi Y, Naiman S, Amir G, et al

Geronotology

SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan

Gerontol. A Biol. Sci. Med. Sci.

Roichman et al.

Genflow Cell Cover 1.2

SIRT6 Is Responsible for More Efficient DNA Double-Strand Break Repair in Long-Lived Species

Cell. 2019 Apr 18;177(3):622-638 

Tian X, Firsanov D, Zhang Z, Cheng Y, Luo L, Tombline G, Tan R, Simon M, Henderson S, Steffan J, Goldfarb A, Tam J, Zheng K, Cornwell A, Johnson A, Yang JN, Mao Z, Manta B, Dang W, Zhang Z, Vijg J, Wolfe A, Moody K, Kennedy BK, Bohmann D, Gladyshev VN, Seluanov A, Gorbunova V.

Genflow Cell Cover 3

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

Cell 124, 315–329 (2006)

Mostoslavsky, R. et al

Genflow Cell Cover 2

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

Cell. 2009;136:62–74.

Kawahara TL, Michishita E, Adler AS, et al

Genflow Pharmacology Cover 2.1

Author manuscript; available in PMC 2019 Aug 1.

Han Dai, David A. Sinclair, James L. Ellis, Clemens Steegborn  Pharmacol Ther.

Genflow Science Aaas Cover 1

Aging genes: the sirtuin story unravels

Science. 2011;334:1194–1198.

Couzin-Frankel J. Genetics

Genflow Science Aaas Cover 2

SIRT6 promotes DNA repair under stress by activating PARP1

Z Mao, C Hine, X Tian, et al. 

Science 332. No.6036. June 2011: 1443-46